PhytophthoraV1, Main, Exploration, bibRecord, 000599

A Novel 'Candidatus Liberibacter asiaticus'-Encoded Sec-Dependent Secretory Protein Suppresses Programmed Cell Death in Nicotiana benthamiana.

Identifieur interne : 000599 ( Main/Exploration ); précédent : 000598; suivant : 000600

A Novel 'Candidatus Liberibacter asiaticus'-Encoded Sec-Dependent Secretory Protein Suppresses Programmed Cell Death in Nicotiana benthamiana.

Auteurs : Chao Zhang [République populaire de Chine] ; Xuefeng Wang [République populaire de Chine] ; Xuelu Liu [République populaire de Chine] ; Yanyan Fan [République populaire de Chine] ; Yongqiang Zhang [République populaire de Chine] ; Xueping Zhou [République populaire de Chine] ; Weimin Li [République populaire de Chine]

Source :

International journal of molecular sciences [ 1422-0067 ] ; 2019.

RBID : pubmed:31752214

Descripteurs français

KwdFr :
- Apoptose (MeSH), Cartographie chromosomique (MeSH), Chromosomes de plante (génétique), Mutation (MeSH), Protéines bactériennes (génétique), Protéines bactériennes (métabolisme), Rhizobiaceae (métabolisme), Signaux de triage des protéines (MeSH), Tabac (cytologie), Tabac (génétique), Tabac (métabolisme), Transfection (MeSH), Végétaux génétiquement modifiés (cytologie), Végétaux génétiquement modifiés (métabolisme).
MESH :
- cytologie : Tabac, Végétaux génétiquement modifiés.
- génétique : Chromosomes de plante, Protéines bactériennes, Tabac.
- métabolisme : Protéines bactériennes, Rhizobiaceae, Tabac, Végétaux génétiquement modifiés.
- Apoptose, Cartographie chromosomique, Mutation, Signaux de triage des protéines, Transfection.

English descriptors

KwdEn :
- Apoptosis (MeSH), Bacterial Proteins (genetics), Bacterial Proteins (metabolism), Chromosome Mapping (MeSH), Chromosomes, Plant (genetics), Mutation (MeSH), Plants, Genetically Modified (cytology), Plants, Genetically Modified (metabolism), Protein Sorting Signals (MeSH), Rhizobiaceae (metabolism), Tobacco (cytology), Tobacco (genetics), Tobacco (metabolism), Transfection (MeSH).
MESH :
- chemical , genetics : Bacterial Proteins.
- chemical , metabolism : Bacterial Proteins.
- cytology : Plants, Genetically Modified, Tobacco.
- genetics : Chromosomes, Plant, Tobacco.
- metabolism : Plants, Genetically Modified, Rhizobiaceae, Tobacco.
- Apoptosis, Chromosome Mapping, Mutation, Protein Sorting Signals, Transfection.

Abstract

'Candidatus Liberibacter asiaticus' (CLas) is one of the causal agents of citrus Huanglongbing (HLB), a bacterial disease of citrus trees that greatly reduces fruit yield and quality. CLas strains produce an array of currently uncharacterized Sec-dependent secretory proteins. In this study, the conserved chromosomally encoded protein CLIBASIA_03875 was identified as a novel Sec-dependent secreted protein. We show that CLIBASIA_03875 contains a putative Sec- secretion signal peptide (SP), a 29 amino acid residue located at the N-terminus, with a mature protein (m3875) of 22 amino acids found to localize in multiple subcellular components of the leaf epidermal cells of Nicotiana benthamiana. When overexpressed via a Potato virus X (PVX)-based expression vector in N. benthamiana, m3875 suppressed programmed cell death (PCD) and the H₂O₂ accumulation triggered by the pro-apoptotic mouse protein BAX and the Phytophthora infestans elicitin INF1. Overexpression also resulted in a phenotype of dwarfing, leaf deformation and mosaics, suggesting that m3875 has roles in plant immune response, growth, and development. Substitution mutagenesis of the charged amino acid (D7, R9, R11, and K22) with alanine within m3875 did not recover the phenotypes for PCD and normal growth. In addition, the transiently overexpressed m3875 regulated the transcriptional levels of N. benthamiana orthologs of CNGCs (cyclic nucleotide-gated channels), BI-1 (Bax-inhibitor 1), and WRKY33 that are involved in plant defense mechanisms. To our knowledge, m3875 is the first PCD suppressor identified from CLas. Studying the function of this protein provides insight as to how CLas attenuates the host immune responses to proliferate and cause Huanglongbing disease in citrus plants.

DOI: 10.3390/ijms20225802
PubMed: 31752214
PubMed Central: PMC6888338

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000344
to stream Main, to step Curation: 000344

Le document en format XML

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 Liberibacter asiaticus'-Encoded Sec-Dependent Secretory Protein Suppresses Programmed Cell Death in <i>Nicotiana benthamiana</i>
.</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Apoptosis (MeSH)</term>
<term>Bacterial Proteins (genetics)</term>
<term>Bacterial Proteins (metabolism)</term>
<term>Chromosome Mapping (MeSH)</term>
<term>Chromosomes, Plant (genetics)</term>
<term>Mutation (MeSH)</term>
<term>Plants, Genetically Modified (cytology)</term>
<term>Plants, Genetically Modified (metabolism)</term>
<term>Protein Sorting Signals (MeSH)</term>
<term>Rhizobiaceae (metabolism)</term>
<term>Tobacco (cytology)</term>
<term>Tobacco (genetics)</term>
<term>Tobacco (metabolism)</term>
<term>Transfection (MeSH)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Apoptose (MeSH)</term>
<term>Cartographie chromosomique (MeSH)</term>
<term>Chromosomes de plante (génétique)</term>
<term>Mutation (MeSH)</term>
<term>Protéines bactériennes (génétique)</term>
<term>Protéines bactériennes (métabolisme)</term>
<term>Rhizobiaceae (métabolisme)</term>
<term>Signaux de triage des protéines (MeSH)</term>
<term>Tabac (cytologie)</term>
<term>Tabac (génétique)</term>
<term>Tabac (métabolisme)</term>
<term>Transfection (MeSH)</term>
<term>Végétaux génétiquement modifiés (cytologie)</term>
<term>Végétaux génétiquement modifiés (métabolisme)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Bacterial Proteins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Bacterial Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Tabac</term>
<term>Végétaux génétiquement modifiés</term>
</keywords>
<keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Plants, Genetically Modified</term>
<term>Tobacco</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Chromosomes, Plant</term>
<term>Tobacco</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Chromosomes de plante</term>
<term>Protéines bactériennes</term>
<term>Tabac</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Plants, Genetically Modified</term>
<term>Rhizobiaceae</term>
<term>Tobacco</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Protéines bactériennes</term>
<term>Rhizobiaceae</term>
<term>Tabac</term>
<term>Végétaux génétiquement modifiés</term>
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<term>Chromosome Mapping</term>
<term>Mutation</term>
<term>Protein Sorting Signals</term>
<term>Transfection</term>
</keywords>
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<term>Cartographie chromosomique</term>
<term>Mutation</term>
<term>Signaux de triage des protéines</term>
<term>Transfection</term>
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<front><div type="abstract" xml:lang="en">'<i>Candidatus</i>
 Liberibacter asiaticus' (CLas) is one of the causal agents of citrus Huanglongbing (HLB), a bacterial disease of citrus trees that greatly reduces fruit yield and quality. CLas strains produce an array of currently uncharacterized Sec-dependent secretory proteins. In this study, the conserved chromosomally encoded protein CLIBASIA_03875 was identified as a novel Sec-dependent secreted protein. We show that CLIBASIA_03875 contains a putative Sec- secretion signal peptide (SP), a 29 amino acid residue located at the N-terminus, with a mature protein (m3875) of 22 amino acids found to localize in multiple subcellular components of the leaf epidermal cells of <i>Nicotiana benthamiana</i>
. When overexpressed via a <i>Potato virus X</i>
 (PVX)-based expression vector in <i>N. benthamiana</i>
, m3875 suppressed programmed cell death (PCD) and the H<sub>2</sub>
O<sub>2</sub>
 accumulation triggered by the pro-apoptotic mouse protein BAX and the <i>Phytophthora infestans</i>
 elicitin INF1. Overexpression also resulted in a phenotype of dwarfing, leaf deformation and mosaics, suggesting that m3875 has roles in plant immune response, growth, and development. Substitution mutagenesis of the charged amino acid (D7, R9, R11, and K22) with alanine within m3875 did not recover the phenotypes for PCD and normal growth. In addition, the transiently overexpressed m3875 regulated the transcriptional levels of <i>N. benthamiana</i>
 orthologs of <i>CNGCs</i>
 (cyclic nucleotide-gated channels), <i>BI-1</i>
 (Bax-inhibitor 1), and <i>WRKY33</i>
 that are involved in plant defense mechanisms. To our knowledge, m3875 is the first PCD suppressor identified from CLas. Studying the function of this protein provides insight as to how CLas attenuates the host immune responses to proliferate and cause Huanglongbing disease in citrus plants.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">31752214</PMID>
<DateCompleted><Year>2020</Year>
<Month>04</Month>
<Day>08</Day>
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<DateRevised><Year>2020</Year>
<Month>04</Month>
<Day>08</Day>
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<Issue>22</Issue>
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<Month>Nov</Month>
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<Title>International journal of molecular sciences</Title>
<ISOAbbreviation>Int J Mol Sci</ISOAbbreviation>
</Journal>
<ArticleTitle>A Novel '<i>Candidatus</i>
 Liberibacter asiaticus'-Encoded Sec-Dependent Secretory Protein Suppresses Programmed Cell Death in <i>Nicotiana benthamiana</i>
.</ArticleTitle>
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<Abstract><AbstractText>'<i>Candidatus</i>
 Liberibacter asiaticus' (CLas) is one of the causal agents of citrus Huanglongbing (HLB), a bacterial disease of citrus trees that greatly reduces fruit yield and quality. CLas strains produce an array of currently uncharacterized Sec-dependent secretory proteins. In this study, the conserved chromosomally encoded protein CLIBASIA_03875 was identified as a novel Sec-dependent secreted protein. We show that CLIBASIA_03875 contains a putative Sec- secretion signal peptide (SP), a 29 amino acid residue located at the N-terminus, with a mature protein (m3875) of 22 amino acids found to localize in multiple subcellular components of the leaf epidermal cells of <i>Nicotiana benthamiana</i>
. When overexpressed via a <i>Potato virus X</i>
 (PVX)-based expression vector in <i>N. benthamiana</i>
, m3875 suppressed programmed cell death (PCD) and the H<sub>2</sub>
O<sub>2</sub>
 accumulation triggered by the pro-apoptotic mouse protein BAX and the <i>Phytophthora infestans</i>
 elicitin INF1. Overexpression also resulted in a phenotype of dwarfing, leaf deformation and mosaics, suggesting that m3875 has roles in plant immune response, growth, and development. Substitution mutagenesis of the charged amino acid (D7, R9, R11, and K22) with alanine within m3875 did not recover the phenotypes for PCD and normal growth. In addition, the transiently overexpressed m3875 regulated the transcriptional levels of <i>N. benthamiana</i>
 orthologs of <i>CNGCs</i>
 (cyclic nucleotide-gated channels), <i>BI-1</i>
 (Bax-inhibitor 1), and <i>WRKY33</i>
 that are involved in plant defense mechanisms. To our knowledge, m3875 is the first PCD suppressor identified from CLas. Studying the function of this protein provides insight as to how CLas attenuates the host immune responses to proliferate and cause Huanglongbing disease in citrus plants.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Zhang</LastName>
<ForeName>Chao</ForeName>
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</AffiliationInfo>
<AffiliationInfo><Affiliation>Biotechnology Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, China.</Affiliation>
</AffiliationInfo>
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<AffiliationInfo><Affiliation>Citrus Research Institute, Southwest University, Chongqing 400712, China.</Affiliation>
</AffiliationInfo>
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</AffiliationInfo>
<AffiliationInfo><Affiliation>Citrus Research Institute, Southwest University, Chongqing 400712, China.</Affiliation>
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</AffiliationInfo>
<AffiliationInfo><Affiliation>College of Life Science, Shandong Normal University, Jinan 250014, China.</Affiliation>
</AffiliationInfo>
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<ForeName>Yongqiang</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Biotechnology Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, China.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Zhou</LastName>
<ForeName>Xueping</ForeName>
<Initials>X</Initials>
<AffiliationInfo><Affiliation>Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100094, China.</Affiliation>
</AffiliationInfo>
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A Novel 'Candidatus Liberibacter asiaticus'-Encoded Sec-Dependent Secretory Protein Suppresses Programmed Cell Death in Nicotiana benthamiana.

A Novel 'Candidatus Liberibacter asiaticus'-Encoded Sec-Dependent Secretory Protein Suppresses Programmed Cell Death in Nicotiana benthamiana.

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